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. 2009 May 13;83(15):7619–7628. doi: 10.1128/JVI.00470-09

FIG. 5.

FIG. 5.

Outcome of SIVmac251 challenge of influenza virus-SIV-vaccinated macaques. Two naïve macaques vaccinated with recombinant influenza virus-SIV expressing the SIV Gag KP9 epitope (H1N1-KP9 and H3N2-KP9) were challenged intravenously with SIVmac251 and serial blood samples analyzed. (A) SIV plasma RNA. Viral load analyses (mean ± standard error) from 48 untreated historical pigtail macaques controls infected with the same SIVmac251 stock from 2 previously studies are shown in gray for comparison. (B) Total peripheral CD4 T cells. (C) SIV Gag KP9-specific CD8 T cells. (D) Expression of the α4β7 integrin on KP9/Mane-A*10 tetramer-positive CD8 T cells. (E) SIV KP9 WT and SIV KP9-K165R escape mutant (EM) virus levels determined by qRT-PCR.