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. 2009 May 20;83(15):7770–7778. doi: 10.1128/JVI.00241-09

FIG. 2.

FIG. 2.

Changes in weight and activity score of ferrets immunized with vaccines formulated with Iscomatrix adjuvant. Ferrets were immunized with vaccines based on the reverse engineered A/Vietnam/1194/04 NIBRG-14 (H5N1) virus containing 1.9, 3.8, 7.5, or 15 μg of HA plus 60 μg of Iscomatrix adjuvant (IMX) or with PBS. Ferrets received two inoculations of vaccine on days 1 and 21 and were challenged with wild-type A/Vietnam/1203/04 virus 3 weeks after the last immunization. (A) Weights of individual ferrets on days 0, 3, 5, 7, and 14 after challenge. (B) Activity scores for each of the indicated days after challenge. Scores are depicted as in Fig. 1.