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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Neurobiol Dis. 2009 Apr 22;35(1):82–90. doi: 10.1016/j.nbd.2009.04.006

Figure 6.

Figure 6

Neutrophil elastase (NE) contribution to post-ischemic vasogenic edema and BBB disruption. (A) ZN200355 (ZN) administration in SW/ND4 mice reduced ipsilateral vasogenic edema at 24 h of reperfusion following 2-h transient middle cerebral artery occlusion (tMCAo). (B) Vasogenic edema was significantly reduced in NE−/− mice versus wild-types following tMCAo. Evans Blue content (μg/hemisphere) 24 h following a 90-min tMCAo, normalized to the contralateral hemisphere, was significantly reduced in (C) SW/ND4 mice given ZN, relative to vehicle, and (D) NE−/− mice versus wild-type controls. Values shown are mean±SEM. *p<0.05 vs. vehicle administration or wild-type.