Averaged fMRI maps (from 2 subjects, 2 single runs, 30-s block design, forepaw stimulation) of anterior coronal slices under halothane showed weak widespread activities beyond contralateral primary (S1) and secondary (S2) somatosensory cortices (A), whereas under α-chloralose demonstrated strong localized activation in contralateral S1 (B). Darker colors represent greater overlap across experiments (i.e., reproducibility). All activation maps were thresholded at the same value (P < 0.02). [Copyright 2007 by The National Academy of Sciences of the USA.]