Table 2.
Proteins Grouped into Eight Co-Expression Clusters Associated with B Cell Proliferative States
| Cluster i | Cluster ii | Cluster iii | Cluster iv |
|---|---|---|---|
| Coronin 1A (isoforms) | hnRNP A2/B1 (isoforms) | Hematopoietic cell-specific | Calreticulin |
| Dihydrolipoyl dehydrogenase | Macrophage capping protein | Lyn substrate 1 | Endoplasmin |
| Alpha enolase | Rho GDI 2 | Hsp 90b | Moesin (isoform) |
| Pyruvate kinase M2 | Coronin 1A (isoform) | Moesin (isoform) | Coronin 1A isoforms |
| LIM and SH3 domain 1 | EF-2 (isoforms) | EF-2 (isoforms) | |
| Cofilin-1 | GRP-78 | ||
| Glutamate dehydrogenase | Coronin 1A (isoform) | ||
| hnRNP L (isoforms) | |||
| High mobility group protein B1 | |||
| Tropomyosin α3 | |||
| Peptidyl-prolyl cis-trans | |||
| isomerase A (isoform) | |||
| Cluster v
|
Cluster vi
|
Cluster vii
|
Cluster viii
|
| Aldose reductase | UTP-glucose-1-phosphate | hnRNP U | Chloride intracellular |
| hnRNP A3 (isoform) | uridylyltransferase 2 (isoform) | Splicing factor 3b | channel protein 1 |
| Serpin b1a protein | High mobility group protein B2 | homologue | Prohibitin |
| hnRNP L (isoform) | Matrin-3 | Ig μ C region | Nucleophosmin |
| Adenylyl cyclase-associated | hnRNP A/B | DEK protein | Unnamed protein product |
| protein 1 | hnRNP H1 (isoform) | Actin-like protein 6A | similar to 30 hypoxia |
| Ran | Hsp 71 | Eukaryotic translation | Up-regulated-1 |
| initiation factor 3 | hnRNP H1 (isoform) | ||
| Vimentin | EF-2 (isoform) | ||
| Peptidyl-prolyl cis-trans | Transitional ER ATPase 1 | ||
| isomerase A (isoform) | hnRNP K | ||
| Tubulin α6 | |||
| hnRNP H1 (isoform) | |||
| Splicing factor 3A |
Many of the spot features included in the expression trend groups shown in Figure 5, or their isoforms were assigned by matrix-assisted laser desorption ionization/time of flight MS and peptide mass fingerprint analyses. Listed are the classifications of the assigned proteins or their isoforms into the expression trend groups i–viii.