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. 2009 Jul;175(1):84–96. doi: 10.2353/ajpath.2009.080870

Figure 3.

Figure 3

Increased oxidative and nitrosative stress in the TSK lung. A: Representative immunohistochemical staining for nitrotyrosine in wild-type and TSK lungs at PD5, PD14, and 2 months of age. Markedly enhanced staining is evident in the TSK lung at the three time points. Inset shows prominent airspace epithelial staining in the PD5 lung. Magnification = original ×20; ×60 (inset). B: Quantitative immunohistochemistry of nitrotyrosine shows enhanced staining in the TSK lung parenchyma. C: Representative 8-deoxyguanine immunohistochemistry in adult wild-type and TSK lungs showing increased staining in the TSK parenchyma. Magnification = original ×20. Arrows denote representative sites of staining in the airspace wall. D: Semiquantitative analysis of 8-hydroxyguanosine staining in adult wild-type and TSK lungs confirming increased staining in the TSK lungs. E: Time course of DCF liberation from lysates of PD5 wild-type and TSK mice. *P < 0.001 and **P < 0.01.