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. 2009 Jul;175(1):132–147. doi: 10.2353/ajpath.2009.081002

Figure 7.

Figure 7

MCP-1 expression in macrophage-depleted wounds. A: MCP-1 mRNA expression during skin repair in PBS- and DTox-injected mice as indicated (left panel). A quantification of MIP-2 mRNA from data points of the respective RNase protection assay gel is shown in the right panel. B: qRT-PCR quantifications of MCP-1 mRNA expression from 7-day wound tissue from five individual mice (n = 5) to demonstrate the individual variability of the respective signal. Bars indicate the mean ± SD obtained from wounds (n = 3) isolated from five individual animals (n = 5). **P < 0.01 (unpaired Student’s t-test) as compared with PBS-treated mice. C: MCP-1 specific ELISA analyses from 5 day (left panel) and 7 day (right panel) wound lysates from PBS- and DTox-injected mice. MCP-1 protein is expressed as pg/50 μg skin or section lysate. Bars indicate the mean ± SD obtained from wounds (n = 2) isolated from five animals (n = 5). *P < 0.05 (unpaired Student’s t-test) as compared with PBS-treated mice.