Table 3.
Deregulated Proteins after E2F1 Induction in U2OS E2F1-ER Cells that Possess E2F1-Responsive Element
| Qualitative changes (see results) | |
| Overexpressed | Suppressed |
| Carbonic anhydrase 2, Carbonate dehydratase II | Mitotic checkpoint protein BUB3 |
| Caldesmon | 10 kd heat shock protein, mitochondrial, Hsp10, CPN10 |
| Collagen alpha-1(I) chain precursor | Elongation factor 1-beta |
| Crk-like protein | Enhancer of rudimentary homolog |
| Alpha crystallin B chain | FK506-binding protein 3 |
| Cold shock domain-containing protein E1 | Heterogeneous nuclear ribonucleoprotein R, hnRNP R |
| COP9 signalosome complex subunit 8, JAB1-containing signal | Nuclear migration protein nudC |
| Cytochrome b5 | T-complex protein 1 subunit delta |
| N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 | Thymidylate synthase |
| Trifunctional enzyme subunit alpha, mitochondrial precursor | UDP-glucose 6-dehydrogenase |
| Keratin, type II cytoskeletal 1 | |
| Leukotriene A-4 hydrolase | |
| Mitochondrial-processing peptidase subunit beta, mitochondrial precursor | |
| 26S proteasome non-ATPase regulatory subunit 11 | |
| Ras-related protein Rab-1A | |
| Heat shock protein 75 kd, mitochondrial precursor | |
| Spliceosome RNA helicase BAT1, DEAD box protein UAP56 | |
| Quantitative changes (see results) | |
| Increased | Decreased |
| Cathepsin B precursor | Splicing factor, arginine/serine-rich 1 |
| Eukaryotic translation initiation factor 3 subunit I | Proliferating cell nuclear antigen |
| Transitional endoplasmic reticulum ATPase, Valosin-containing protein | Vimentin |
| Prohibitin | |
| Thioredoxin-like protein 1 | |
| Chloride intracellular channel protein 1 | |
| Heterogeneous nuclear ribonucleoprotein K | |