Figure 1.

Tumorigenic response of K5.RasGRP1 transgenic mice to skin wounding. A: Representative photographs of skin tumors (arrows) developed in the transgenic mice at week 3 and 10 after a 3-cm full-thickness incision wound was performed on the dorsal skin. B: Tumor incidence (percentage of mice with tumors) in wild-type (open circle) and K5.RasGRP1 transgenic (closed circle) mice subjected to wounding. C: Representative microphotographs of H&E-stained tumors developed in the transgenic mice subjected to wounding. Pap, papilloma; SCC, squamous cell carcinoma.