Figure 3.

Choroidal thickness at the posterior pole was found to reduce with age in the CFH-deficient mouse and C3 deposition increased compared with wild-type. The choroidal thickness was significantly reduced in the aged cfh^−/− mouse compared with that in the age-matched control and the 3-month-old cfh^−/− mouse (A) (P < 0.0001). Choroidal flat mounts revealed almost total absence of C3 deposition in aged wild-type retinae (arrow in B), while extensive deposition of complement C3 (green) was observed in the aged cfh^−/− (arrow in C). Scale bar = 10 μm.