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. 2009 Jul;175(1):422–429. doi: 10.2353/ajpath.2009.081033

Figure 2.

Figure 2

Kaplan-Meier analysis of HO-1+/+ and HO-1−/− recipients of allogeneic aortic grafts following treatment with CORM-2 or iCORM-2. All HO-1+/+ recipient mice treated with CORM-2 or iCORM-2 survived the entire 8-week follow-up period. In contrast, all eight HO-1−/− recipient mice treated with iCORM-2 died with arterial thrombosis within 4 days after transplantation (median survival time = 1 day). Five of eight CORM-2-treated HO-1 knockout mice (62.5%) survived to 8 weeks (median survival time = 56 days, *P < 0.01 in comparison with iCORM-2-treated animals). There was no statistical difference between CORM-2-treated group and HO-1+/+ groups (#P = 0.08).