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. 2009 Jul;175(1):422–429. doi: 10.2353/ajpath.2009.081033

Figure 3.

Figure 3

Histological evaluation of aortic grafts. No arterial thrombus can be seen 24 hours after transplantation in the allogeneic grafts of HO-1+/+ recipient animals treated with either iCORM-2 (A, n = 5) or CORM-2 (B, n = 5). C: All iCORM-2-treated HO-1−/− recipients contained arterial thrombi at 24 hours after transplantation (n = 5) H&E staining; original magnification, ×200; scale bar = 100 μm. D: HO-1−/− mice treated with CORM-2 showed little or no arterial thrombi at 24 hours after transplantation (n = 5). E: Mean patency of allogeneic aortic grafts in HO-1+/+ and HO-1−/− recipient animals treated with iCORM-2 or CORM-2. CORM-2 treatment significantly increased the mean patency of grafts in HO-1−/− recipients (67 ± 12.2%) in comparison with HO-1−/− mice treated with iCORM-2 (5.0 ± 4.8%, P < 0.01). F: Hind-limb function at 24 hours after transplantation. The severity of hind-limb paralysis was graded using a scoring system as described in Materials and Methods.