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The co-crystal structures of HCV-796 binding to the palm domain of HCV NS5B polymerase. A, crystal structure details of HCV-796 binding to NS5B570-Con1 (genotype 1b) with cysteine at position 316 (pink highlight). B, crystal structure details of HCV-796 binding to NS5B570-BK (1b) carrying asparagine at position 316 (pink highlight). C, modeling of HCV-796 binding to NS5B protein with tyrosine at position 316 (orange highlight).
