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Ki or IC50values for inhibition of rPACE4, hPC5/6, hPC7, and α-thrombin by small molecule inhibitors
Ki and IC50 values were determined as described under “Experimental Procedures.” S.E. for each determination was ≤10.3%.
| Enzyme | Compound |
|||
|---|---|---|---|---|
| DC1 | DC2 | DC3 | B3 | |
| μm | ||||
| ssfurina | 1.0 | 3.3 | 6.1 | 12 |
| rPACE4 | 13 | 8.3 | 14 | 12 |
| hPC5/6 | 4.0 | 3.0 | 16 | 76 |
| hPC7 | 79 | 12 | 91 | 4.5 |
| α-Thrombin | 21 | 60 | 15 | 63 |
a Data fromFig. 2 for comparison.
