TABLE 3.

Toxicity of small molecule inhibitors in cell culture under conditions of tests of inhibition of processing

J774A.1 murine mac ro phages were incubated in RB* with DC1 (20 ×K_i), DC2 (20 ×K_i), DC3 (20 ×K_i), DC4 (20 ×K_i), or B3 (2 ×K_i) for times as shown. Toxicity was determined as described under “Anthrax Toxin Killing Assays” under “Experimental Procedures.” Cells in triplicate wells (∼600 cells per well) were counted for each time point. Average S.E.: 8.3% for DC1, 7.6% for DC2, 7.2% for DC3, 10.3% for DC4, and 13.9% for B3.

Time	Compound
	DC1	DC2	DC3	DC4	B3
h
0	100	100	100	100	100
2.5	98	96	97	96	85
6	95	96	98	95	80
8	86	83	90	94	60