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. 2009 Jul 24;5(7):e1000579. doi: 10.1371/journal.pgen.1000579

Figure 2. Mapping of the OI mutation.

Figure 2

SNP genotypes of selected CFA 21 markers are shown. Alternate SNP alleles are represented in blue and yellow. The two copies of CFA 21 for each dog are separated by a vertical dashed line. The analysis of SNP genotypes from five affected dogs indicated that they had extended homozygous regions on CFA 21 (indicated as blue blocks). The boundaries of these homozygous blocks are given in Mb. All five affected dogs had homozygous intervals with shared alleles between 23.58 Mb and 29.40 Mb. We also genotyped five parents of affected dogs assumed to be carriers of the mutation. One of these carriers, animal no. 33, had one copy of the disease-associated haplotype in the critical interval (indicated in blue). In comparison to the affected dogs it was homozygous for the opposite SNP alleles (indicated in yellow) at several positions proximal of 24.66 Mb and distal of 29.40 Mb. Thus – assuming that it resides on the common blue haplotype block – the causative mutation is located within the interval from 24.66 Mb to 29.40 Mb on CFA 21.