Table 2. Correlations between HBD2 and IL1β, IL8 & IL10 production from unstimulated, LPS- and LPS+nicotine-stimulated biopsies obtained from patients and controls.
| Biopsies | Correlation with IL1β | Correlation with IL8 | Correlation with IL10 | ||||||
| Disease, stimulation and inflammation | Spearman r | 95% CI | p value | Spearman r | 95% C I | p value | Spearman r | 95% CI | p value |
| CD: unstimulated | |||||||||
| All | 0.0155 | −0.420–0.455 | 0.945 | −0.0885 | −0.586–0.457 | 0.754 | 0.429 | −0.004–0.727 | 0.0463 |
| Inflamed | 0.470 | exact | 0.213 | 0.0985 | Exact | 0.840 | 0.608 | exact | 0.0863 |
| Uninflamed | −0.575 | −0.860– −0.0173 | 0.0396 | −0.347 | Exact | 0.389 | 0.298 | −0.319–0.738 | 0.322 |
| CD: LPS-stimulated | |||||||||
| All | −0.115 | −0.552–0.335 | 0.611 | −0.179 | −0.643–0.381 | 0.523 | 0.521 | 0.114–0.778 | 0.0129 |
| Inflamed | 0.259 | exact | 0.493 | 0.216 | Exact | 0.662 | 0.783 | Exact | 0.0172 |
| Uninflamed | −0.357 | −0.766–0.259 | 0.231 | −0.310 | Exact | 0.462 | 0.371 | −0.243–0.773 | 0.212 |
| CD: LPS+nicotine stimulated | |||||||||
| All | 0.178 | −0.276–0.567 | 0.428 | 0.171 | −0.389–0.638 | 0.542 | 0.274 | −0.180–0.632 | 0.217 |
| Inflamed | 0.377 | exact | 0.313 | 0.0721 | Exact | 0.906 | 0.851 | exact | 0.0061 |
| Uninflamed | −0.0664 | −0.607–0.517 | 0.829 | 0.317 | Exact | 0.428 | −0.0724 | −0.611–0.512 | 0.814 |
| UC: unstimulated | |||||||||
| All | 0.291 | −0.121–0.617 | 0.149 | 0.690 | 0.281–0.887 | 0.0031 | 0.261 | −0.153–0.597 | 0.198 |
| Inflamed | 0.374 | −0.111–0.715 | 0.115 | 0.890 | 0.634–0.970 | 0.0001 | 0.283 | −0.211–0.661 | 0.241 |
| Uninflamed | −0.0935 | exact | 0.840 | 0.738 | exact | 0.333 | 0.115 | exact | 0.840 |
| UC: LPS-stimulated | |||||||||
| All | 0.130 | −0.282– 0.502 | 0.527 | 0.771 | 0.432–0.919 | 0.0005 | 0.456 | 0.0712–0.723 | 0.0192 |
| Inflamed | 0.071 | −0.409–0.519 | 0.774 | 0.947 | 0.810–0.986 | <0.0001 | 0.434 | −0.0403–0.748 | 0.0637 |
| Uninflamed | 0.0591 | exact | 0.906 | 0.775 | exact | 0.333 | −0.307 | exact | 0.498 |
| UC: LPS+nicotine stimulated | |||||||||
| All | 0.234 | −0.181–0.578 | 0.251 | 0.808 | 0.531–0.937 | 0.0001 | 0.421 | 0.0285–0.701 | 0.0320 |
| Inflamed | 0.313 | −0.179–0.680 | 0.192 | 0.873 | 0.588–0.965 | 0.0002 | 0.489 | 0.0300–0.778 | 0.0337 |
| Uninflamed | −0.0371 | exact | 0.964 | 0.949 | Exact | 0.0833 | −0.231 | exact | 0.595 |
| HC: unstimulated | 0.0561 | −0.397–0.487 | 0.809 | 0.229 | −0.238–0.610 | 0.319 | 0.516 | 0.0948–0.781 | 0.0167 |
| HC: LPS-stimulated | −0.0589 | −0.489–0.394 | 0.799 | 0.607 | 0.224–0.827 | 0.0035 | 0.294- | −0.171–0.652 | 0.195 |
| HC: LPS+nicotine stimulated | 0.337 | −0.125–0.678 | 0.136 | 0.503 | 0.0771–0.773 | 0.0202 | 0.266 | −0.201–0.634 | 0.244 |