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Lipocalin 2 up-regulation is TLR4 dependent. Littermate controls (□) and KO mice (■) were infected and sacrificed after 4 h, n = 4–6 animals/cohort. Lung homogenates were analyzed by ELISA for lipocalin 2 levels. TLR4 KO animals are unable to up-regulate lipocalin 2 protein levels after 4 h of infection, while p19 KO, p35 KO, and p40 KO animals retained this ability.
