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. Author manuscript; available in PMC: 2010 Apr 15.
Published in final edited form as: J Immunol. 2009 Apr 15;182(8):4947–4956. doi: 10.4049/jimmunol.0803282

FIGURE 9.

FIGURE 9

Recombinant lipocalin 2 rescues Lcn2 KO from KP infection. A, Lcn2 KO mice were infected and are susceptible as demonstrated by bacterial loads in lung homogenates after 4 and 12 h of infection (four animals per cohort). B, Extrapulmonary dissemination of KP to the spleen is also increased in the same Lcn2 KO animals compared with controls at 12 h of infection. C, Reconstituting Lcn2 KO mice with recombinantly expressed lipocalin 2 protein (Lcn 2) results in statistically significant reduction in lung bacterial load at 12 h of infection in these mice compared with Lcn2 KO mice that did not receive Lcn 2 (six animals per cohort). D, Wet:dry ratios in Lcn2 KO mice receiving Lcn 2 are significantly lower compared with Lcn2 KO mice that did not receive Lcn 2. Data reflect six mice per group. *, Statistical significance compared with WT and **, statistical significance compared with untreated KO.