Table 1.
Phenotypic characteristics of study participants
| PCOS (n = 624)
|
Minimally phenotyped controls (n = 472)
|
Intensively phenotyped controls (n = 72)
|
||||
|---|---|---|---|---|---|---|
| n | Median (range) | n | Median (range) | n | Median (range) | |
| Age | 624 | 28 (14–48) | 472 | 35 (18–45) | 72 | 29 (18–40) |
| BMI (kg/m2) | 624 | 35.0 (16.5–64.5)a | 463 | 23.2 (16.7–68.1) | 72 | 27.7 (18.0–53.5) |
| Waist circumference (cm) | 408 | 101 (58–170)a | ND | ND | 61 | 85 (63–134) |
| T (ng/dl) [(mmol/liter)] | 624 | 73 (29–337)b [2.5 (1.0–11.7)]b | ND | ND | 72 | 28 (6–49) [1.0 (0.2–1.7)] |
| uT (ng/dl) [(mmol/liter)] | 621 | 24 (1.7–109)b [0.8 (0.06–3.8)]b | ND | ND | 72 | 7.0 (1–16.0) [0.2 (0.03–0.6)] |
| DHEAS (ng/ml) [(μmol/liter)] | 616 | 2091 (50–13,336)b [5.7 (0.1–36.2)]b | ND | ND | 70 | 1363 (390–3484) [3.7 (1.1–9.5)] |
| SHBG (nmol) | 514 | 56 (12–426)b | ND | ND | 30 | 104 (46–331) |
| Fasting insulin (μU/ml) [(pmol/liter)] | 601 | 22 (3–152)b [132 (18–912)] | ND | ND | 65 | 11 (4–29) [66 (24–174)] |
| Fasting glucose (mg/dl) [(mmol/liter)] | 607 | 88 (58–189) [4.9 (3.2–10.5)] | ND | ND | 71 | 89 (72–130) [5.0 (4.0–7.2)] |
| HDL (mg/dl) [(mmol/liter)] | 577 | 40 (15–107)b [1.03 (0.39–2.77)]b | ND | ND | 57 | 49 (27–85) [1.27 (0.70–2.20)] |
| TTG (mg/dl) [(mmol/liter)] | 578 | 137 (35–2427)b [3.54 (0.91–62.76)]b | ND | ND | 57 | 78 (37–306) [0.88 (0.41–3.45)] |
a
P < 0.0001 vs. intensively phenotyped controls;
b
P < 0.0001 vs. intensively phenotyped controls after adjusting for BMI and age. ND, Not determined.
Conversion factors: uT and T, nanograms per deciliter to millimoles per liter, multiply by 0.03467; DHEAS, nanograms per milliliter to micromoles per liter, multiply by 0.002714; insulin, microunits per milliliter to picomoles per liter, multiply by 6.0; glucose, milligrams per deciliter to millimoles per liter, multiply by 0.05551; HDL, milligrams per deciliter to millimoles per liter, multiply by 0.02586; TTG, milligrams per deciliter to millimoles per liter, multiply by 0.01129.