Table 2.
Effect of NES and T gel on serum gonadotropins
| Group
|
|||||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | |
| T gel dose (g) | 0 | 0 | 10 | 10 | 10 | 10 | 10 |
| NES gel dose (mg) | 2 | 4 | 0 | 2 | 4 | 6 | 8 |
| Evaluable (n) | 16 | 16 | 19 | 19 | 15 | 18 | 16 |
| d-1 LH (IU/liter)a | 3.3 (2.8–4.1) | 3.4 (2.1–4.5) | 3.7 (3.1–5.5) | 3.2 (2.4–4.7) | 3.7 (2.6–4.5) | 3.6 (2.5–4.7) | 3.3 (2.5–4.8) |
| LH, % decreaseb | 41 (18–54) | 56 (13–65) | 71 (32–85) | 85 (55–96) | 91 (57–97) | 95 (83–97) | 96 (89–97) |
| d-1 FSH (IU/liter)a | 3.2 (1.4–3.8) | 2.5 (1.7–3.8) | 2.4 (2.1–4.8) | 2.0 (1.8–3.8) | 3.5 (2.4–5.3) | 3.2 (2.2–4.3) | 3.1 (2.4–3.9) |
| FSH, % decreaseb | 27 (21–35) | 37 (29–54) | 52 (22–80) | 75 (60–89) | 76 (42–96) | 92 (74–95) | 93 (82–96) |
| Men with d-21 LH and FSH ≤0.5 IU/literc | 0, 0 (0–21) | 0, 0 (0–21) | 4, 21.1 (6–46) | 7, 36.8 (16–62) | 6, 40.0 (16–68) | 11, 61.1 (36–83) | 11, 68.8 (41–89) |
| Men with d-21 LH and FSH ≤1 IU/literc | 1, 6.3 (0–30) | 2, 12.5 (2–38) | 6, 31.6 (13–57) | 11, 57.9 (34–80) | 8, 53.3 (27–79) | 13, 72.2 (47–90) | 13, 81.3 (54–96) |
a
Results shown as median (first to third quartiles).
b
Results shown as median (first to third quartiles) for percent decrease from d 1–21; P < 0.05 for percent decreases in all groups.
c
Results shown as number, percentage, and 95% confidence interval for percentage.