Table 1.
Baseline clinical and hormonal characteristics of NC and HA subjects
| Tanner 1-2 NC (n = 4) | Tanner 3-5 NC (n = 18) | Tanner 3-5 HA (n = 24) | |
|---|---|---|---|
| Age (yr) | 9.7 ± 1.6 (0.8, 9.5)b | 13.9 ± 1.9 (0.5, 13.9) | 16.1 ± 1.7 (0.3, 16.0)b |
| Years postmenarche | NA | 1.5 ± 1.9 (0.4, 0.7) | 3.6 ± 1.8 (0.4, 3.0)b |
| BMI (kg/m2) | 20.2 ± 6.2 (3.1, 17.2) | 22.0 ± 3.9 (0.9, 21.4) | 33.9 ± 7.6 (1.6, 33.3)c |
| BMI-for-age percentile | 68 ± 21 (10, 62) | 67 ± 28 (7, 79) | 92 ± 17 (3, 98)c |
| Total T (ng/dl) | 5.4 ± 1.9 (0.9, 5.1)c | 22.1 ± 8.6 (2.0, 22.5) | 51.3 ± 17.1 (3.5, 49.4)c |
| SHBG (nmol/liter) | 26.5 ± 14.6 (7.3,26.6) | 36.2 ± 16.5 (3.9, 32.9) | 16.8 ± 9.7 (2.0, 13.6)c |
| Free T (pg/ml) | 1.1 ± 0.4 (0.2,1.1)b | 4.0 ± 2.0 (0.5, 3.2) | 13.5 ± 5.2 (1.1, 13.4)c |
| DHEAS (mg/dl) | 53.8 ± 39.0 (19.5, 47.5)a | 122.8 ± 59.4 (14.4, 112.0) | 138.8 ± 68.3 (14.0, 125.5) |
| Androstenedione (ng/ml) | 0.7 ± 0.3 (0.1, 0.7)b | 1.5 ± 0.5 (0.1, 1.5) | 2.2 ± 1.0 (0.2, 1.9)b |
| E1 (pg/ml) | 29.0 ± 10.8 (5.4, 29.6) | 39.3 ± 19.8 (4.7, 34.8) | 55.5 ± 20.7 (4.2, 53.8)a |
| E2 (pg/ml) | 37.8 ± 21.1 (10.6, 43.9) | 57.0 ± 16.9 (4.0, 57.0) | 63.3 ± 18.1 (3.7, 61.7) |
| P (ng/ml) | 0.4 ± 0.1 (0.1, 0.3) | 0.4 ± 0.2 (0.0, 0.4) | 0.6 ± 0.2 (0.0, 0.6)b |
| LH (IU/liter) | 1.5 ± 1.6 (0.8, 1.1)b | 5.6 ± 3.2 (0.8, 4.7) | 7.9 ± 4.4 (0.9, 7.3) |
| FSH (IU/liter) | 2.0 ± 1.2 (0.6, 2.1)b | 4.6 ± 1.5 (0.4, 4.4) | 3.9 ± 0.8 (0.2, 3.8) |
| Fasting insulin (mIU/ml) | 17.2 ± 21.3 (10.6, 9.1) | 21.5 ± 12.0 (2.8, 18.3) | 28.7 ± 22.8 (4.6, 22.7) |
Data are presented as mean± sd (sem, median). NA, Not applicable.
a
P < 0.05;
b
P < 0.01;
c
P < 0.001 vs. Tanner 3-5 NC.