Table 2.
Effects of 7 d of oral E2 and P in NC and HA adolescent girls
| Tanner 1-2 NC (n = 4) | Tanner 3-5 NC (n = 18) | Tanner 3-5 HA
|
|||
|---|---|---|---|---|---|
| All (n = 24) | P-sensitive (n = 15) | P-insensitive (n = 9) | |||
| Day 0 | |||||
| E2 (pg/ml) | 38 ± 21 (11, 44) | 57 ± 17 (4, 57) | 63 ± 18 (4, 62) | 67 ± 14 (4, 66) | 57 ± 24 (8, 54) |
| P (ng/ml) | 0.4 ± 0.1 (0.1, 0.3) | 0.4 ± 0.2 (0.0, 0.4) | 0.6 ± 0.2 (0.0, 0.6)b | 0.6 ± 0.1 (0.0, 0.6) | 0.6 ± 0.2 (0.1, 0.6) |
| FSH (IU/liter) | 2.0 ± 1.2 (0.6, 2.1)b | 4.6 ± 1.5 (0.4, 4.4) | 3.9 ± 0.8 (0.2, 3.8) | 3.8 ± 0.5 (0.1, 3.8) | 4.0 ± 1.1 (0.4, 3.5) |
| LH (IU/liter) | 1.5 ± 1.6 (0.8, 1.1)b | 5.6 ± 3.2 (0.8, 4.7) | 7.9 ± 4.4 (0.9, 7.3) | 7.7 ± 3.7 (1.0, 7.5) | 8.4 ± 5.5 (1.8, 6.4) |
| LH pulses/11 h | 5.3 ± 3.0 (1.5, 5.0) | 6.9 ± 1.7 (0.4, 7.0) | 9.5 ± 1.4 (0.3, 9.5)c | 10.0 ± 1.0 (0.3, 10.0) | 8.8 ± 1.6 (0.6, 8.0)d |
| Mean LH amplitude (IU/liter) | 1.4 ± 1.0 (0.5, 1.7)b | 4.3 ± 2.0 (0.5, 3.8) | 3.3 ± 2.0 (0.4, 2.8)a | 3.0 ± 1.5 (0.4, 2.9) | 3.7 ± 2.7 (0.9, 2.7) |
| Day 7 | |||||
| E2 (pg/ml) | 145 ± 50 (25, 148) | 166 ± 103 (24, 139) | 122 ± 47 (10, 117) | 128 ± 49 (13, 114) | 114 ± 44 (15, 123) |
| P (ng/ml) | 5.3 ± 1.2 (0.6, 5.7) | 6.8 ± 3.8 (0.9, 6.3) | 7.7 ± 2.9 (0.6, 7.9) | 6.9 ± 2.0 (0.5, 7.6) | 8.9 ± 3.9 (1.3, 9.7) |
| FSH (IU/liter) | 0.1 ± 0.2 (0.1, 0.0)c | 2.8 ± 1.7 (0.4, 2.3) | 3.2 ± 0.8 (0.2, 3.0) | 3.1 ± 0.5 (0.1, 3.0) | 3.4 ± 1.1 (0.4, 2.9) |
| LH (IU/liter) | 0.1 ± 0.1 (0.0, 0.1)c | 5.2 ± 4.7 (1.1, 5.0) | 6.6 ± 3.1 (0.6, 6.0) | 6.4 ± 3.1 (0.8, 6.4) | 7.0 ± 3.3 (1.1, 5.1) |
| LH pulses/11 h | 0.3 ± 0.5 (0.3, 0.0)b | 3.5 ± 2.0 (0.5, 4.0) | 6.3 ± 1.5 (0.3, 6.5)c | 5.7 ± 1.4 (0.4, 6.0) | 7.3 ± 0.9 (0.3, 8.0)e |
| Mean LH amplitude (IU/liter) | 0.3g | 7.9 ± 5.8 (1.4, 6.3) | 5.3 ± 2.9 (0.6, 4.3) | 5.7 ± 3.2 (0.8, 4.5) | 4.6 ± 2.4 (0.8, 3.9) |
| Reduction in LH pulses | |||||
| Absolute | 5.0 ± 2.6 (1.3, 5.0) | 3.4 ± 1.4 (0.3, 3.0) | 3.3 ± 1.9 (0.4, 3.5) | 4.3 ± 1.2 (0.3, 5.0) | 1.4 ± 1.3 (0.4, 1.0)f |
| Percent | 97 ± 6 (3, 100)b | 51 ± 26 (6, 45) | 33 ± 18 (4, 33)a | 43 ± 12 (3, 44) | 15 ± 12 (4, 14)f |
| % Reduction LH pulses/d 7 P | 19.3 ± 5.8 (2.9, 17.8)a | 10.3 ± 7.7 (1.8, 8.2) | 4.7 ± 3.4 (0.7, 4.6)b | 6.7 ± 2.8 (0.7, 5.9) | 1.5 ± 1.0 (0.3, 1.5)f |
Data are presented as mean± sd (sem, median).
a
P < 0.05 vs. Tanner 3-5 NC;
b
P < 0.01 vs. Tanner 3-5 NC;
c
P < 0.001 vs. Tanner 3-5 NC;
d
P < 0.05 vs. HA P-sensitive;
e
P < 0.01 vs. HA P-sensitive;
f
P < 0.001 vs. HA P-sensitive;
g
Only one pulse was present in the Tanner 1-2 NC population on d 7.