Table 3.
Clinical and hormonal characteristics of Tanner 3-5 HA P-sensitive and P-insensitive subjects
| HA P-sensitive (n = 15) | HA P-insensitive (n = 9) | |
|---|---|---|
| Age (yr) | 16.0 ± 1.5 (0.4, 16.1) | 16.2 ± 2.1 (0.7, 16.0) |
| Years postmenarche | 3.7 ± 1.7 (0.4, 3.0) | 3.6 ± 2.0 (0.7, 0.9) |
| BMI (kg/m2) | 34.1 ± 8.1 (2.1, 31.8) | 33.4 ± 7.0 (2.3, 33.6) |
| BMI-for-age percentile | 93 ± 10.3 (3, 96) | 89 ± 24 (8, 98) |
| Ethnicity (no. of subjects) | ||
| Hispanic | 8 | 1 |
| Non-Hispanic | 7 | 8 |
| Baseline | ||
| Total T (ng/dl) | 55.8 ± 16.2 (4.2, 59.0) | 43.7 ± 16.5 (5.5, 49.0) |
| SHBG (nmol/liter) | 16.6 ± 8.5 (2.2, 15.1) | 16.9 ± 12.0 (4.0, 12.3) |
| Free T (pg/ml) | 14.3 ± 4.7 (1.2, 12.6) | 12.0 ± 6.1 (2.0, 14.0) |
| DHEAS (μg/dl) | 137 ± 72 (21, 126) | 153 ± 75 (25, 162) |
| Androstenedione (ng/ml) | 2.3 ± 1.1 (0.3, 2.0) | 1.9 ± 0.6 (0.2, 1.7) |
| E1 (pg/ml) | 57.7 ± 20.2 (5.2, 61.0) | 51.7 ± 22.1 (7.4, 38.6) |
| E2 (pg/ml) | 66.9 ± 13.6 (3.5, 65.9) | 57.3 ± 23.6 (7.9, 54.2) |
| P (ng/ml) | 0.6 ± 0.1 (0.0, 0.6) | 0.6 ± 0.2 (0.1, 0.6) |
| LH (IU/liter) | 7.7 ± 3.7 (1.0, 7.5) | 8.4 ± 5.5 (1.8, 6.4) |
| FSH (IU/liter) | 3.8 ± 0.5 (0.1, 3.8) | 4.0 ± 1.1 (0.4, 3.5) |
| Fasting insulin (μIU/ml) | 22.2 ± 13.9 (3.6, 18.1) | 39.6 ± 30.6 (10.2, 29.4)a |
| Day 7 | ||
| Total T (ng/dl) | 50.8 ± 14.4 (3.7, 50.1) | 46.6 ± 19.0 (6.3, 44.0) |
| SHBG (nmol/liter) | 19.4 ± 10.1 (2.6, 17.9) | 18.9 ± 13.2 (4.4, 14.7) |
| Free T (pg/ml) | 12.2 ± 3.9 (1.0, 11.7) | 12.1 ± 6.4 (2.1, 11.7) |
| Androstenedione (ng/ml) | 1.9 ± 0.8 (0.2, 1.7) | 1.8 ± 0.6 (0.2, 1.7) |
| E1 (pg/ml) | 142 ± 52 (13, 146) | 161 ± 64 (22, 149) |
| E2 (pg/ml) | 128 ± 49 (13, 114) | 114 ± 44 (15, 123) |
| P (ng/ml) | 6.9 ± 2.0 (0.5, 7.3) | 8.9 ± 3.9 (1.3, 9.7) |
| LH (IU/liter) | 6.4 ± 3.1 (0.8, 6.4) | 7.0 ± 3.3 (1.1, 5.1) |
| FSH (IU/liter) | 3.1 ± 0.5 (0.1, 3.0) | 3.4 ± 1.1 (0.4, 2.9) |
Data are presented as mean ± sd (sem, median). Insulin levels on d 7 were not reported because subjects were not fasting secondary to snack given with 2300 h dose of P.
a
P = 0.02.