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. Author manuscript; available in PMC: 2009 Jul 10.
Published in final edited form as: Biochim Biophys Acta. 2007 Feb 20;1770(6):927–932. doi: 10.1016/j.bbagen.2007.02.002

Figure 2. BBS treatment causes activation of PI3K/Akt/GSK-3β pathway in neuroblastoma cells.

Figure 2

(A, B) BBS treatment caused rapid phosphorylation of Akt and GSK-3β, which was decreased by GRP receptor antagonists and completely abrogated by LY294002. (B) BBS-induced GSK-3β phosphorylation was also inhibited by SB216763 and SB415286. Values under blots represent protein fold-change levels (relative to respective β-actin) in comparison to control lane.