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. Author manuscript; available in PMC: 2009 Jul 10.
Published in final edited form as: Biochim Biophys Acta. 2007 Feb 20;1770(6):927–932. doi: 10.1016/j.bbagen.2007.02.002

Figure 3. GRP/BBS modulates G1/S-phase regulators in neuroblastoma cells by the PI3K pathway.

Figure 3

(A) SK-N-SH cells demonstrated increased phospho-Akt, cyclin D and phospho-Rb expression, while displaying decreased p21, and p27, with GRP treatment. (B) LAN-1 cells exhibited increased phospho-Akt and cyclin D and decreased p27 with BBS treatment. (C) BBS-induced changes to G1/S-phase regulator cyclin D in BE(2)-C cells were blocked with LY294002 (membrane in Figure 2A was stripped and reprobed). Values under blots represent protein fold-change levels (relative to respective β-actin) in comparison to control lane.