Table 3.
Details of 13 cases of chronic/recalcitrant pseudophakic cystoid macular edema treated with nepafenac 0.1%
| Case | Previous treatment | Length of previous treatment | Pre-treatment retinal thickness (μm) | Post-treatment retinal thickness (μm) | Retinal thickness improvement (μm) | Pre-treatment VA (logMAR VA) | Post-treatment VA (logMAR VA) | VA improvement (logMAR) | Current treatment |
|---|---|---|---|---|---|---|---|---|---|
| #9 | ketorolac + prednisolone | 1 month | 216 | 183 | 33 | 20/200 (1.00) | 20/60 (0.48) | 0.52 | Nepafenac 0.1% TID 1 month |
| #10 | prednisolone | 1 month | 499 | 291 | 208 | 20/40 − 1 (0.32) | 20/30 + 1 (0.16) | 0.16 | Nepafenac 0.1% TID 1 month |
| #11 | prednisolone | 1 month | 327 | 278 | 49 | 20/60 + 1 (0.46) | 20/40 + 1 (0.28) | 0.18 | Nepafenac 0.1% TID 2 months |
| #12 | ketorolac + prednisolone | 6 months | 690 | 262 | 428 | 20/60 (0.48) | 20/30 (0.18) | 0.30 | Nepafenac 0.1% TID 1 month |
| #13 | None | Not applicable | 699 | 413 | 286 | 20/300 − 1 (1.20) | 20/60 + 1 (0.46) | 0.74 | Nepafenac 0.1% TID 4 + months + prednisolone acetate QID 2 months |
| #14 OD | ketorolac + prednisolone | 16 months intermittently | 454 | 187 | 267 | 20/80 + 1 (0.58) | 20/40 + 1 (0.28) | 0.30 | Nepafenac 0.1% TID 8 + months |
| #14 OS | ketorolac + prednisolone, IVT | 16 months intermittently | 524 | 180 | 344 | 20/80 (0.60) | 20/40 − 1 (0.32) | 0.28 | Nepafenac 0.1% TID 6 + months |
| #15 | ketorolac + prednisolone | 7 months | 418 | 235 | 183 | 20/100 (0.70) | 20/40 (0.30) | 0.40 | Nepafenac 0.1% TID 3 months |
| #16 | ketorolac + prednisolone | 2 months | 411 | 257 | 154 | 20/200 (1.00) | 20/60 − 1 (0.50) | 0.50 | Nepafenac 0.1% TID 2.25 + months |
| #17 | ketorolac + prednisolone | 3 months | 377 | 267 | 110 | 20/40 (0.30) | 20/25 + 1 (0.08) | 0.22 | Nepafenac 0.1% TID 6 months |
| #18 | ketorolac | 3 months | 585 | 441 | 144 | 20/200 (1.00) | 20/60 (0.48) | 0.52 | Nepafenac 0.1% TID 3 + months |
| #19 | flurbiprofen + prednisolone | 4 months | 367 | 232 | 135 | 20/25 − 1 (0.12) | 20/20 (0) | 0.12 | Nepafenac 0.1% TID 1 month |
| #20 | ketorolac + prednisolone | 6 weeks | 294 | 322 | −28 | 20/60 (0.48) | 20/50 (0.40) | 0.08 | Nepafenac 0.1% TID + prednisolone acetate QID 1 + month |
| Total mean data ± SD | 451 ± 145.7 | 273 ± 80.8 | 178 ± 128.7 | 0.63 ± 0.33 | 0.30 ± 0.16 | 0.33 ± 0.19 | |||
Note: Patient #13 had untreated CME for 24 months prior to nepafenac treatment.
Abbreviations: IVT, intravitreal triamcinolone; QID, four times daily; SD, standard deviation; TID, three times daily; VA, visual acuity.