Skip to main content
. 2009 Jun 2;3:81–87.

Table 1.

Protocol for the concentration and exposure time of mitomycin C during trabeculectomy based on risk factors for excessive postoperative fibrosis

Risk factors Value
Age: less than 10 years 3
Age: 10–25 years 2
Age: 25–40 years 1
Age: greater than 70 years −1
Black 1
Sturge-Weber syndrome 2
Uveitis – inactive 2
Uveitis – active 4
Neovascular glaucoma 4
Repeat filtration (1 trab/no antimetabolites)§ 2
Repeat filtration (1 trab/5-FU)§ 3
Repeat filtration (1 trab/MMC)§ 4
Repeat filtration (2 or more trab)§ 4
PCIOL* with virgin conjunctiva in 1 or 2 superior quadrants 1
PCIOL* with scar in superior quadrants 2
ACIOL without vitreous in the AC 2
ACIOL with vitreous in the AC 3
Aphakia 3
Other surgery with conjunctival scarring 1
Score Concentration Exposure time**
1 to 2 0.2 mg/ml 1–2 minutes
3 to 4 0.3 mg/ml 3–4 minutes
5 and over 0.4 mg/ml 5–6 minutes

Notes: *PCIOL, posterior chamber intraocular lens;

ACIOL, anterior chamber intraocular lens;

AC, anterior chamber;

§

trab, trabeculectomy;

Score = sum of risk factor values;

**

Actual exposure times were adjusted at the time of surgery according to bleeding, scar tissue and thickness of Tenon capsule.