Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pax6 downregulates Sox2 in the lens equator. (A,B) Immunofluorescent detection of Sox2 (green) and Ap2α (red) in E14.5 control (A) and Pax6lox/lox;Mlr10 (B) mouse lenses. Arrowheads in B indicate elevated expression of Sox2 at the lens equator and in the posterior lens. (A′,B′) Counterstaining of A,B with DAPI. (C) Quantification of Sox2 protein by confocal image analysis (n=6, **P<0.001). eq, lens equator; LE, lens epithelium; re, retina. Scale bar: 100 μm.
