Disc1 repressed foxd3 and sox10 expression.
(A) Injection of 200 pg of gfp mRNA into one cell of a two- to
four-cell-stage embryo resulted in unilateral expression at 5s. Dotted line
outlines the edge of the embryo. (B-E) Asymmetrical overexpression of
the human ortholog of disc1 resulted in a unilateral loss of
foxd3 (B,C) and sox10 (D,E) expression (arrows). Expression
of myod1 was normal. Dorsal views with anterior to the left.
(F-I) Overexpression of Foxd3 resulted in an expansion of
sox10 expression (arrows in H,I) similar to that seen in Disc1
morphants. F and G are lateral views, H and I, dorsal views, both with
anterior to the left.