Table 1.

Short description of the terms and their combinations used in this work.

scoring function	Description
torsion	Extended torsion potential over 3 consecutive residues. Bin sizes: 45 degree for the centre residue, 90 degree for the 2 adjacent residues
pair residue	Residue-level, secondary structure specific interaction potential using Cβ atoms as interaction centres. Range 3...25 Å, step size: 1 Å
solvation	Potential reflecting the propensity of a certain amino acid for a certain degree of solvent exposure based on the number of Cβ atoms within a sphere of 9 Å around the centre Cβ.
pair all-atom	All-atom, secondary structure specific interaction potential using all 167 atom types. Range 3...20 Å, step size: 0.5 Å
SSE agreement	Agreement between the predicted secondary structure of the target sequence (using PSIPRED) and the calculated secondary structure of the model (using DSSP).
ACC agreement	Agreement between the predicted relative solvent accessibility using ACCpro (buried/exposed) and the relative solvent accessibility derived from DSSP (> 25% accessibility => exposed)
QMEAN3	linear combination of torsion, pair residue, salvation
QMEAN4	linear combination of torsion, pair residue, solvation, pair all-atom
QMEAN5	linear combination torsion, pair residue, solvation, SSE, ACC
QMEAN6	linear combination of torsion, pair residue, solvation, pair all-atom, SSE, ACC