Fig. 1.

Coordinated expression of lysosomal proteins. Panels represent the following protein pairs: Panel A, chitobiase (CTBS) and plasma α-fucosidase (FUCA2), r² = 0.673; Panel B, β-mannosidase (MANBA) and β-galactosidase (GLB1), r² = 0.662; Panel C, β-glucuronidase (GUSB) and glucosamine (N-acetyl)-6-sulfatase (GNS), r² = 0.655; Panel D, SGSH and glucosamine (N-acetyl)-6-sulfatase, r² = 0.648; Panel E, β-glucuronidase and SGSH, r² = 0.640; Panel F, CTSD and glucosamine (N-acetyl)-6-sulfatase, r² = 0.480. For all plots, the linear relationship when considering controls and cases in aggregate was statistically significant (p < 0.0001), and the strength of the respective correlation is indicated by r² values calculated from the Pearson correlation coefficient. Each point represents the spectral counts of the indicated two proteins associated with a given specimen with the raw data presented in supplemental Table 3. Filled and unfilled circles represent cases and controls, respectively.