Table II. Existing protective antigens for GBS.
The list shows reported Group B Streptococcus protective antigens. The presence or not on the COH1 genome and its identification on the surface proteome is reported for each antigen.
| Protein annotation (gene locusa) | Predicted protein localizationb | Presence of the gene in COH1 genome | Presence of the protein in COH1 surface proteome |
|---|---|---|---|
| C5a peptidase (SAN_1369) (17, 18) | Cell wall | Yes | Yes |
| SIP (SAN_0040) (19, 20) | Extracellular | Yes | Yes |
| LrrG (SAN_0509) (21) | Cell wall | Yes | Yes |
| PI-1 subunits (SAN_0698; SAN_0702) (5, 25, 26) | Cell wall | Yes | Yes (SAN_0698) |
| PI-2a subunits (5, 25, 26) | Cell wall | No | No |
| PI-2b subunits (SAN_1518; SAN_1519) (5, 25, 26) | Cell wall | Yes | Yes (SAN_1518) |
| Rib proteinc (22–24) | Cell wall | Yes | No |
aGene locus names according to NCBI and The Institute for Genomic Research.
btProtein localization as predicted by PSORTb v2.0.
ctThe COH1 genome is an unfinished sequence in “assembly” phase: 10 sequences are annotated as Rib proteins or surface protein Rib (SAN_0524, SAN_0528, SAN_2343, SAN_2398, SAN_2418, SAN_2435, SAN_2436, SAN_2437, SAN_2438, and SAN_2439). No peptide was identified from any of these sequences.