Table 4.
Association Analysis of Seven HCN2 Variants
| c.858T>C | Number | C/C | C/T | T/T | f(C) | P*(df1) | P**(df2) | |
|---|---|---|---|---|---|---|---|---|
| Controls | 455 | 0.004 | 0.185 | 0.811 | 0.097 | |||
| IGE | 450 | 0.007 | 0.191 | 0.802 | 0.102 | 0.695 | 0.868 | |
| CAE | 122 | 0.000 | 0.189 | 0.811 | 0.094 | 0.909 | 0.762 | |
| IAE | 196 | 0.005 | 0.214 | 0.781 | 0.112 | 0.394 | 0.672 | |
| JME | 193 | 0.010 | 0.171 | 0.819 | 0.096 | 0.962 | 0.628 | |
| c.1239G>C | Number | G/G | G/C | C/C | f(G) | P*(df1) | P**(df2) | |
|
| ||||||||
| Controls | 275 | 0.000 | 0.131 | 0.869 | 0.065 | |||
| IGE | 393 | 0.005 | 0.094 | 0.901 | 0.052 | 0.305 | 0.167 | |
| CAE | 96 | 0.000 | 0.115 | 0.885 | 0.057 | 0.689 | ||
| IAE | 163 | 0.000 | 0.086 | 0.914 | 0.043 | 0.165 | ||
| JME | 175 | 0.011 | 0.114 | 0.874 | 0.069 | 0.855 | 0.184 | |
| Exon 5 c.1584+7C>T | Number | T/T | C/T | C/C | f(T) | P*(df1) | P**(df2) | |
|
| ||||||||
| Controls | 459 | 0.000 | 0.052 | 0.948 | 0.026 | |||
| IGE | 452 | 0.000 | 0.035 | 0.965 | 0.018 | 0.219 | ||
| CAE | 122 | 0.000 | 0.041 | 0.959 | 0.020 | 0.615 | ||
| IAE | 197 | 0.000 | 0.036 | 0.964 | 0.018 | 0.360 | ||
| JME | 193 | 0.000 | 0.047 | 0.953 | 0.023 | 0.767 | ||
| Intron 6 c.1825+22_1825+42del21 | Number | 171/171 | 171/192 | 192/192 | f(171) | P*(df1) | P**(df2) | |
|
| ||||||||
| Controls | 460 | 0.026 | 0.313 | 0.661 | 0.183 | |||
| IGE | 453 | 0.024 | 0.292 | 0.684 | 0.184 | 0.924 | 0.971 | |
| CAE | 124 | 0.022 | 0.258 | 0.713 | 0.190 | 0.803 | 0.688 | |
| IAE | 197 | 0.027 | 0.284 | 0.689 | 0.180 | 0.917 | 0.907 | |
| JME | 195 | 0.021 | 0.305 | 0.674 | 0.192 | 0.680 | 0.878 | |
| Intron 7 c.1990+24_1990+57dup34 | Number | 200/200 | 200/234 | 234/234 | f(200) | P*(df1) | P**(df2) | |
|
| ||||||||
| Controls | 460 | 0.252 | 0.506 | 0.241 | 0.505 | |||
| IGE | 456 | 0.265 | 0.493 | 0.242 | 0.505 | 0.998 | 0.991 | |
| CAE | 124 | 0.251 | 0.508 | 0.235 | 0.480 | 0.474 | 0.741 | |
| IAE | 198 | 0.253 | 0.506 | 0.242 | 0.503 | 0.923 | 0.983 | |
| JME | 196 | 0.272 | 0.473 | 0.255 | 0.500 | 0.857 | 0.910 | |
| rs10408159 (c.1218+663C>T) | Number | T/T | C/T | C/C | f(T) | P*(df1) | P**(df2) | |
|
| ||||||||
| Controls | 275 | 0.015 | 0.218 | 0.767 | 0.124 | |||
| IGE | 393 | 0.015 | 0.219 | 0.766 | 0.125 | 0.954 | 0.997 | |
| CAE | 95 | 0.011 | 0.211 | 0.779 | 0.116 | 0.775 | 0.944 | |
| IAE | 163 | 0.026 | 0.215 | 0.761 | 0.132 | 0.772 | 0.752 | |
| JME | 175 | 0.000 | 0.217 | 0.783 | 0.109 | 0.494 | 0.275 | |
| rs4919872 (c.1584+985C>T) | Number | T/T | C/T | C/C | f(T) | P*(df1) | P**(df2) | |
|
| ||||||||
| Controls | 275 | 0.244 | 0.462 | 0.295 | 0.475 | |||
| IGE | 383 | 0.232 | 0.457 | 0.311 | 0.461 | 0.623 | 0.891 | |
| CAE | 93 | 0.237 | 0.484 | 0.280 | 0.478 | 0.926 | 0.932 | |
| IAE | 159 | 0.245 | 0.453 | 0.302 | 0.472 | 0.936 | 0.982 | |
| JME | 169 | 0.249 | 0.420 | 0.331 | 0.459 | 0.643 | 0.645 | |
P*
: Two-sided type I error rate for comparisons of allele frequencies;
P**
: Two-sided type I error rate for comparisons of genotype frequencies.
IGE, idiopathic generalized epilepsy; CAE, childhood absence epilepsy; IAE, idiopathic absence epilepsy; JME, juvenile myoclonic epilepsy.