. Author manuscript; available in PMC: 2009 Jul 13.

Published in final edited form as: Cell Cycle. 2008 Nov 15;7(21):3417–3427. doi: 10.4161/cc.7.21.6982

Table 2. p53 activation by JJ78:1 analogues shown in terms of their relative potency order with the most potent analogue assigned as 1.

Compound	C₃	C₄	C₅	Aryl substituents	Potency order
JJ78:12	CH₃	COAr	CH₃	3′-Cl	1
JJ78:13	CH₃	CH₂Ar	CH₃	2′,5′-F₂	4
JJ78:14	CH₃	COAr	CH₃	2′-OMe	=3
JJ78:15	CH₃	COAr	CH₃	2′-OH	=3
JJ78:16	CH₃	COAr	CH₃	2′-(morpholin-4-yl)-5′-F	2
JJ78:17	H	COAr	H	2′,5′-F₂	Inactive
JJ78:18	H	H	COAr	3′-Cl	Inactive