Table 2.
Transmission disequilibrium analysis of 10 TNF/LTA SNPs in 152 parent-offspring trio families
| SNP | Positiona | MAFb | M:Cc | T:Ud | ORe | L95e | U95e | χ 2 f | p Valueg |
|---|---|---|---|---|---|---|---|---|---|
| rs928815 | 5′ LTA | 0.406 | T:G | 48:69 | 0.6957 | 0.4813 | 1.005 | 3.769 | 0.052 |
| rs909253 | LTA-intron 1 | 0.396 | C:T | 81:39 | 2.077 | 1.417 | 3.043 | 14.7 | 0.00012 |
| rs746868 | LTA-intron 1 | 0.400 | C:G | 40:59 | 0.678 | 0.4538 | 1.013 | 3.646 | 0.056 |
| rs1041981 | LTA-exon 3 | 0.391 | A:C | 80:38 | 2.105 | 1.431 | 3.097 | 14.95 | 0.00011 |
| rs1800750 | 5′ of TNF | 0.003 | A:G | 0:1 | / | / | / | 1 | 0.317 |
| rs1800629 | 5′ of TNF | 0.269 | A:G | 65:28 | 2.321 | 1.491 | 3.616 | 14.72 | 0.00012 |
| rs361525 | 5′ of TNF | 0.006 | A:G | 0:7 | / | / | / | 7 | 0.00815 |
| rs3093662 | TNF-intron 1 | 0.038 | G:A | 9:16 | 0.5625 | 0.2486 | 1.273 | 1.96 | 0.162 |
| rs3093665 | TNF-3′UTR | 0.032 | C:A | 9:9 | 1 | 0.397 | 2.519 | 0 | 1 |
| rs3093668 | 3′ of TNF | 0.003 | C:G | 0:6 | / | / | / | 6 | 0.014 |
a
Position of the SNP within the gene.
b
MAF in T1DM children.
c
Minor allele (M) vs. common allele (C).
d
Copies of the minor allele transmitted (T) and nontransmitted (U).
e
Odds ratios (OR) with 95% lower and upper confidence intervals (L95,U95).
f
Chi square (χ2) test.
g
p Value after 10,000 permutations.