Table 2.

Sites I–VIII in saSST and acINV, mutations made as well as amino acid number are shown for both enzymes

Site	saSST	activity	acINV	Activity
I	M173L	Wild type	L201M	Wild type
II	C203N	>Hydrolysis	N251C	Wild type
III	Y248V	None	V276Y	None
IV	Y317W	Wild type	W343Y	Wild type
V	L322F	Wild type	F348L	Wild type
VI	F362Y	>Hydrolysis	Y394F	None
VII	Y408sW	Low	W440Y	>Transferase
VIII	N425S	≫hydrolysis	S457N	Wild type