Table 4.
Sleep Latency (minutes) | WASO (minutes) | Sleep Efficiency (%) | |
---|---|---|---|
Polysomnography‡ | |||
Baseline | 19.7 (21.5) | 121.8 (54.2) | 68.1 (12.2) |
Single Night | |||
Valerian | 12.6 (6.1) | 122.6 (66.4) | 67.4 (15.2) |
Placebo | 14.4 (10.9) | 139.9 (65.2) | 66.5 (15.8) |
Two-weeks | |||
Valerian | 20.3 (15.8) | 139.5 (60.4) | 65.7 (13.8) |
Placebo | 15.6 (9.8) | 128.6 (61.0) | 68.1 (11.1) |
Actigraphy‡ | |||
First Week | |||
Valerian | NA | 47.1 (16.8) | 83.9 (6.7) |
Placebo | 47.9 (15.7) | 84.0 (5.7) | |
Second Week | |||
Valerian | NA | 53.8 (24.3) | 83.4 (5.6) |
Placebo | 48.6 (22.4) | 84.4 (4.6) |
Wilcoxon signed-ranks, two-sided, were used to evaluate the primary outcome valerian versus placebo, all p > .05.
Polysomnography: baseline = mean of Night 1 and Night 2, single night = Night 3/31 only, two-week dose = mean of the last two dosing nights (Nights 15 & 16/Nights 43 & 44). Actigraphy: baseline = mean of last five screening nights, first week = mean of the first five home nights (Nights 4-8/Nights 32-36), and second week = mean of the last five home nights (Nights 10-14/Nights 38-42).