Table 1.
Polymorphisms in selected candidate genes and melanoma risk
| Polymorphism | Cases (%) | Controls (%) | OR (95%CI)1 | OR (95%CI)2 |
|---|---|---|---|---|
| MGMT 84 Leu>Phe (rs12917) | ||||
| Wt | 152 (71.0) | 168 (79.2) | 1.00 | 1.00 |
| Het | 60 (28.0) | 43 (20.3) | 1.55 (0.99, 2.44) | 1.44 (0.87, 2.37) |
| Var | 2 (0.9) | 1 (0.5) | ||
| P value | 0.06 | 0.16 | ||
| MGMT 143 Ile>Val (rs2308321) | ||||
| Wt | 154 (72.0) | 164 (77.4) | 1.00 | 1.00 |
| Het | 54 (25.2) | 46 (21.7) | 1.34 (0.86, 2.09) | 1.25 (0.76, 2.05) |
| Var | 6 (2.8) | 2 (0.9) | ||
| P value | 0.19 | 0.39 | ||
| ICAM5 301 Val>Ile (rs1056538) | ||||
| Wt | 85 (39.9) | 68 (32.7) | 1.00 | 1.00 |
| Het | 97 (45.5) | 108 (51.9) | 0.70 (0.46, 1.08) | 0.78 (0.49, 1.26) |
| Var | 31 (14.6) | 32 (15.4) | 0.75 (0.42, 1.36) | 0.80 (0.41, 1.55) |
| P value | 0.25 | 0.58 | ||
| ICAM5 −542 C>G (rs281439) | ||||
| Wt | 126 (59.4) | 130 (61.6) | 1.00 | 1.00 |
| Het | 71 (33.5) | 76 (36.0) | 1.10 (0.75, 1.63) | 1.04 (0.68, 1.62) |
| Var | 15 (7.1) | 5 (2.4) | ||
| P value | 0.63 | 0.85 | ||
| VEGF 398 G>C (rs2010963) | ||||
| Wt | 88 (42.3) | 93 (46.7) | 1.00 | 1.00 |
| Het | 100 (48.1) | 85 (42.7) | 1.25 (0.83, 1.89) | 1.14 (0.72, 1.81) |
| Var | 20 (9.6) | 21 (10.6) | 1.02 (0.51, 2.02) | 1.38 (0.64, 2.96) |
| P value | 0.55 | 0.68 | ||
| VEGF 1967 C>T (rs3025039) | ||||
| Wt | 157 (75.1) | 163 (79.9) | 1.00 | 1.00 |
| Het | 49 (23.4) | 39 (19.1) | 1.35 (0.84, 2.15) | 1.47 (0.86, 2.49) |
| Var | 3 (1.4) | 2 (1.0) | ||
| P value | 0.21 | 0.16 | ||
| MPO −764 T>C (rs2243828) | ||||
| Wt | 131 (63.0) | 112 (56.9) | 1.00 | 1.00 |
| Het | 68 (32.7) | 76 (38.6) | 0.78 (0.51, 1.19) | 0.90 (0.57, 1.44) |
| Var | 9 (4.3) | 9 (4.6) | 0.85 (0.32, 2.26) | 0.87 (0.29, 2.65) |
| P value | 0.50 | 0.89 | ||
| TNF-α −487 A>G (rs1800629) | ||||
| Wt | 156 (73.6) | 140 (66.4) | 1.00 | 1.00 |
| Het | 46 (21.7) | 61 (28.9) | 0.67 (0.43, 1.05) | 0.63 (0.38, 1.04) |
| Var | 10 (4.7) | 10 (4.7) | 0.89 (0.36, 2.22) | 0.91 (0.33, 2.48) |
| P value | 0.21 | 0.20 | ||
Wt: wild type; Het: heterozygote; Var: homozygous variant.
The number of participants does not sum to total women because of missing data on genotype.
Some percentages among cases or controls do not sum to 100% due to rounding.
The p values were calculated based upon 2-degree-of-freedom (df) test for ICAM5 301 Val>Ile, VEGF 398 G>C, TNF-α −487 A>G, and MPO −764 T>C; 1 df test for the other SNPs.
Unconditional logistic regression adjusted for the matching variables (age and race (Caucasians and missing)).
Unconditional logistic regression adjusted for matching variables, constitutional susceptibility score, family history of melanoma, number of lifetime severe sunburns that blistered (0, 1–5, 6–11, or >11), sunlamp use or tanning salon attendance (yes/no), cumulative sun exposure while wearing a bathing suit, and geographic region.