TABLE 3.
Multivariable-adjusted hazard ratios (and 95% CIs), attributable fractions, and population attributable fractions for all-cause mortality and the composite outcome of predialysis all-cause mortality or end-stage renal disease associated with concentrations of serum albumin, percentage of lymphocytes in the white blood cell (WBC) count, and WBC count below or above the median value1
| Serum albumin ≤3.7 (n = 547) vs >3.7 g/dL (n = 673) | Percentage of lymphocytes in WBC ≤22 (n = 587) vs >22% (n = 633) | WBC >7500 (n = 625) vs ≤7500/mL (n = 595) | |
| All-cause mortality | |||
| Hazard ratio (95% CI) | |||
| Fixed-covariate | 1.7 (1.4, 2.0) | 1.3 (1.1, 1.6) | 1.1 (0.9, 1.3) |
| Time-dependent | 2.0 (1.6, 2.4) | 1.8 (1.5, 2.1) | 1.3 (1.1, 1.5) |
| Composite outcome | |||
| Hazard ratio (95% CI) | |||
| Fixed-covariate | 1.5 (1.2, 1.7) | 1.3 (1.1, 1.5) | 1.0 (0.9, 1.2) |
| Time-dependent | 1.9 (1.6, 2.2) | 1.7 (1.4, 2.0) | 1.2 (1.0, 1.4) |
| Attributable fraction | |||
| Mortality percent (95% CI) | |||
| Fixed-covariate | 42 (31, 50) | 34 (23, 44) | 3 (−13, 17) |
| Time-dependent | 56 (48, 63) | 56 (48, 63) | 22 (9, 34) |
| Composite outcome percent (95% CI) | |||
| Fixed-covariate | 47 (38, 54) | 30 (19, 40) | 1 (−15, 15) |
| Time-dependent | 55 (48, 62) | 52 (44, 59) | 15 (1, 26) |
| Population attributable fraction | |||
| Mortality percent (95% CI) | |||
| Fixed-covariate | 11 (8, 15) | 12 (8, 16) | 4 (0, 8) |
| Time-dependent | 38 (31, 45) | 40 (33, 47) | 9 (1, 16) |
| Composite outcome percent (95% CI) | |||
| Fixed-covariate | 12 (9, 14) | 9 (6, 12) | 3 (1, 6) |
| Time-dependent | 37 (31, 43) | 37 (31, 43) | 7 (1, 13) |
Hazard ratios were determined in fixed covariate and time-dependent Cox models. All Cox models were adjusted for age, race, Charlson comorbidity index, diabetes mellitus, cardiovascular disease, smoking, systolic and diastolic blood pressure, BMI, estimated glomerular filtration rate, serum calcium, serum phosphorus, hemoglobin, bicarbonate, blood cholesterol, and 24-h urinary protein. Attributable factions were calculated based on incidence rate differences, and population attributable fractions were estimated from Poisson regressions.