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. 2009 May 5;284(27):18143–18151. doi: 10.1074/jbc.M109.004804

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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sFIGURE 8. — Prevention of cell death by anti-ASC antibody. a, stimulation of oocytes co-expressing pannexin 1 and P2X7 receptor with 500 μm ATP for 4 min resulted in membrane breakdown (arrow) at a time when pannexin 1 and P2X7 currents had dissipated. b, preinjection (1 h) of 6 ng of anti-ASC prevented membrane breakdown, and oocytes survived repeated applications of ATP. c, preinjection of an unrelated rabbit IgG (Cx43; 1.5 ng) did not prevent membrane breakdown following ATP application. d, immunoblotting of oocyte lysates (Oo) with ASC antibody reveals the presence of ASC. The identity of the second band reacting with the anti-ASC antibody is not known. Neuronal lysates (N) served as control. e, quantitative analysis of cell death. The fraction of oocytes with membrane breakdown is plotted.