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. 2009 May 7;284(27):18302–18310. doi: 10.1074/jbc.M109.016717

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — PALB2 elevates cell survival following DNA damage by restoring homologous recombination repair. A, EUFA1341 cells were transduced with vector control or HA-FLAG-tagged wild-type PALB2 (WT), the C-terminal deletion mutant (ΔC32), and the N-terminal deletion mutant (ΔN42). PALB2 expression was confirmed by Western blot (WB) as indicated. B, clonogenic assay after MMC treatment indicated that both the N-terminal and C-terminal regions of PALB2 are required for cell survival after MMC treatment. Results are the averages of three independent experiments. C and D, gene conversion in EUFA1341 reconstituted with wild-type or mutant PALB2. GFP-positive cells indicative of gene conversion (R1) were quantified by flow cytometry analysis. Results are the average of three independent experiments and were presented as mean ± S.E.