Table 1.

Receptor Tyrosine Kinases Subject to Intramembrane Proteolysis^*

Receptor Tyrosine Kinase	Stimulating Ligand	ICD
		Location	Functional Evidence
ErbB-4	neuregulin, TPA	cytoplasm, nucleus, mitochondria	yes
Ephrin	ephrin, ionomycin	cytoplasm, nucleus	no
CSF-1R	CSF-1, LPS, TPA	cytoplasm, nucleus	no
Tie 1	VEGF, TPA	cytoplasm	yes
VEGFR1	PEDGF	cytoplasm	yes
Insulin, IGF-1	TPA	cytoplasm	no

^*References are in the text.