Table 3.
Intact Receptors Trafficked to Nucleus or Mitochondria
| Receptor Tyrosine Kinase | Stimulating Ligand | Organelle | Functional Evidence | References |
|---|---|---|---|---|
| ErbB-1 | EGF | nucleus | yes | [53,57,127,60,52,56,54,55,58] |
| ErbB-1 | Src | mitochondria | no | [128] |
| ErbB-1 vIII | none | nucleus | yes | [129] |
| ErbB-2 | over-expression | nucleus | yes | [130,131] |
| ErbB-3 | none | nucleus | no | [132] |
| FGF-R1, R2 | FGF | nucleus | yes | [133,134](ref therein) |
| IFN-γR1 | IFN-γ | nucleus | yes | [135–137] |
| TrkA | NGF, LPS | nucleus | no | [138,139] |
| TGF-β | TGF-β | nucleus | no | [140] |
| GH | Growth hormone | nucleus | yes | [141–143] |
| IL-15R2 | IL-15 | nucleus | no | [144] |
| VEGFR1/FLT1 | VEGF | nucleus | no | [145–147] |
| Met | HGF | nucleus | no | [148] |