Fig. 2.
Temporal patterns of Per1, Per2, Bmal1, Cry1 and rev-erbα mRNA expression in the cerebellum of suckle control (SC, ■), gastrostomy control (GC, ●), and alcohol-treated (EtOH, Δ) rats during exposure to constant darkness. Symbols denote mean (±SEM) determinations of mRNA abundance in cerebellar tissue (n = 4 to 5) at 6-hour intervals. The plotted values correspond to the ratios of Per1, Per2, Bmal1, Cry1 or rev-erbα / CypA mRNA signal in which the maximal value for each gene was set at 100%. Asterisks indicate time points during which peak values for cerebellar expression of a given gene were significantly greater (p < 0.05) than those observed during preceding or succeeding minima.