Table 1.
GST | Ki (μM)1 | |||
---|---|---|---|---|
NO2-LA | NO2-LA-SG | NO2-OA | NO2-OA-SG | |
GSTA4-4 | 0.46 ± 0.01 | 0.32 ± 0.03 | 0.53 ± 0.10 | 0.57 ± 0.05 |
GSTA1-1 | 0.15 ± 0.02 | 0.78 ± 0.004 | 0.11 ± 0.02 | 0.67 ± 0.04 |
GSTM1a-1a | 0.007 ± 0.002 | 0.010 ± 0.04 | 0.028 ± 0.007 | 0.026 ± 0.005 |
GSTP1a-1a | 0.069 ± 0.014 | 0.079 ± 0.001 | 0.033 ± 0.005 | 0.048 ± 0.001 |
Ki were determined from nitroalkene (Figure 6) and nitroalkene-glutathione conjugate (not shown) inhibition data as described in Experimental Procedures. Shown are mean values ± 1 sd from 3 independent determinations.