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. Author manuscript; available in PMC: 2009 Jul 13.
Published in final edited form as: European J Org Chem. 2008;(31):5254–5262. doi: 10.1002/ejoc.200800651

Table 2.

Domino Heck–aza-Michael.[a]

graphic file with name nihms-116068-f0004.jpg
Entry Additive Water [mol-%] % Conv.[b]
1 – – 35
2 Bu4NCl – 72
3 Bu4NCl 10 mol-% 95
4 Bu4NI – 68
5 Bu4NI 10 mol-% 94
[a]

Reaction conditions: 1 (0.12 mmol), Pd (2 mol-%), methyl acrylate (0.36 mmol), Et3N (0.36 mmol) and Bu4NCl (0.12 mmol) in DMF at 110 °C for 14 h.

[b]

Conversion by G.C.