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. Author manuscript; available in PMC: 2009 Jul 13.
Published in final edited form as: European J Org Chem. 2008;(31):5254–5262. doi: 10.1002/ejoc.200800651

Table 4.

Demonstration of a one-pot domino protocol.[a]

graphic file with name nihms-116068-f0007.jpg
Entry R1 R2 R3 Product % Yield[b]
1 H c-C5H9 Me 7 74
2 H c-C6H11 OH 8 86
3 4-F Bn OEt 9 84
4 4-F C8H17 OH 10 90
5 H 4-ClPh OEt 11 81
6 4-F c-C6H11 OH 12 84
7 H 4-MeOPh OMe 13 84
[a]

Reaction conditions: 1 (0.12 mmol), Pd2(dba)3·CHCl3 (2mol-%), methyl acrylate (0.36 mmol), Bu4NCl (0.12 mmol) in DMF at 110 °C for 14 h.

[b]

Isolated yields.