Table 4.
| |||||
---|---|---|---|---|---|
Entry | R1 | R2 | R3 | Product | % Yield[b] |
1 | H | c-C5H9 | Me | 7 | 74 |
2 | H | c-C6H11 | OH | 8 | 86 |
3 | 4-F | Bn | OEt | 9 | 84 |
4 | 4-F | C8H17 | OH | 10 | 90 |
5 | H | 4-ClPh | OEt | 11 | 81 |
6 | 4-F | c-C6H11 | OH | 12 | 84 |
7 | H | 4-MeOPh | OMe | 13 | 84 |
Reaction conditions: 1 (0.12 mmol), Pd2(dba)3·CHCl3 (2mol-%), methyl acrylate (0.36 mmol), Bu4NCl (0.12 mmol) in DMF at 110 °C for 14 h.
Isolated yields.