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. Author manuscript; available in PMC: 2009 Jul 13.
Published in final edited form as: European J Org Chem. 2008;(31):5254–5262. doi: 10.1002/ejoc.200800651

Table 5.

Application of domino HAM protocol with 15.[a]

graphic file with name nihms-116068-f0008.jpg
Entry R1 R2 Product % Yield[b]
1 4-MeOPh Me 16 88
2 C8H17 OMe 17 84
3 4-MeOPh OMe 18 93
4 2-MeOBn OEt 19 86
[a]

Reaction conditions: 1 (0.12 mmol), Pd2(dba)3·CHCl3 (2mol-%), methyl acrylate (0.36 mmol), Bu4NCl (0.12 mmol) in DMF at 110 °C for 14 h.

[b]

Isolated yields. Compounds purified by mass-directed fractionation.