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. 2009 Jul 22;4(7):e6334. doi: 10.1371/journal.pone.0006334

Figure 3. Central effects of HN on glucose metabolism involve hypothalamic STAT-3 activation.

Figure 3

A) Effects of ICV HN or aCSF on pSTAT-3Tyr705 levels in hypothalamic protein extracts. B) Effects of ICV HN and F6AHN on the levels of totalSTAT-3, pAKTS473, insulin receptor (IR) and pAMPKThr172 in the hypothalamus (aCSF -black bars, HN -white bars, F6AHN-grey, n = 5 each). Effects of a STAT-3 inhibitor co-infused ICV with HN or aCSF (n = 6 each) on C) GIR, D) peripheral glucose uptake, and E) HGP and degree of suppression of HGP. Values are means±SE. *Significantly different from other experimental groups, P<0.05.